Conference Proceedings Research Articles

Conceptual Model for the Assessment of Academic Productivity in Research Seedbeds From a Systematic Review

<p style="text-align: justify;">Higher education institutions have focused their efforts on promoting research seedbeds as a strategy for formative research. In this regard, the impact of such a strategy remains unknown due to the lack of models that enable its evaluation. Therefore, this study aimed to design an evaluation model for the academic productivity of research seedbeds based on the available evidence in the literature. To achieve this, a systematic review was conducted following the PRISMA model, analyzing 53 documents including articles, book chapters, and conference proceedings from the SCOPUS, ProQuest, Jstor, Scielo, and ScienceDirect databases. The results identified indicators that allowed for the design of a model based on six constructs: research training, institutional capabilities, bibliographic production, innovation and development, social appropriation of knowledge, and human resource training. It was concluded that the indicators evaluating research seedbeds seek greater scientific development involving students and improving the quality of research products, which directly impacts the institutional research mission.</p>

What do we know about the perpetrators of sexual homicide of adult victims? A systematic review and qualitative meta-synthesis

Introduction: sexual homicide is defined as lethal violence associated with sexual elements or motivations, predominantly perpetrated by men against women. Despite being a less frequent crime, there is a growing clinical and forensic interest in its specificities and the characteristics of the aggressor. Objective: to review the scientific literature on men who commit sexual homicide against adult victims. Methods: systematic review with MeSH ((“Sex Offenses”[Mesh]) AND “Homicide”[Mesh]) in the databases of MEDLINE, LILACS, MENDELEY and SciELO, between 1992 and 2023. The PICO strategy was used with the studied population (male sexual offenders), intervention (homicide of adult victims), context (sexual violence), and outcome (potential relationship between the issues). The stages of article selection and analysis involved two independent researchers. Original studies were included, excluding reviews, editorials, conference proceedings, books and chapters, theses, and dissertations. The selected articles were presented through qualitative meta-synthesis. Results: of the 70 selected articles, 66 articles (94.2%) adopted quantitative methods, 2 (2.9%) qualitative design, and 2 (2.9%) case reports. We found 41 articles (58.6%) conducted in North America and 22 articles (31.4%) in Europe, totaling 63 articles (90.0%). Another five articles (7.1%) were from Asia, one (1.4%) from Africa, and one (1.4%) from Oceania. In 52 articles (74.3%), there was an emphasis on aspects related to psychiatric, behavioral, or psychological disorders of the perpetrator, sexual sadism, or forms of sexual violence or lethal outcomes employed. Conclusion: sexual homicidal men possess characteristics that set them apart from other homicidal offenders or those who commit sexual violence, directing their crimes towards a heterogeneous group of adult victims. Studies have focused on the psychiatric and behavioral disorders of the perpetrator, as well as the relationship with traumatic experiences in childhood.

Pulmonary hypertension survival and hospitalisations in people living with HIV: a systematic review and meta-analysis

IntroductionPeople living with HIV (PLHIV) have a higher risk of developing pulmonary hypertension (PH) with subsequent poorer prognosis. This review aimed to determine the (1) survival outcomes and (2) proportion...

REVIEW OF WORKFORCE UPSKILLING INITIATIVES FOR EMERGING TECHNOLOGIES IN IT

This study provides a comprehensive analysis of workforce upskilling initiatives for emerging technologies in the Information Technology (IT) sector, with the primary objective of identifying effective strategies to prepare professionals for the rapidly evolving digital landscape. Employing a systematic literature review and content analysis, the research scrutinizes various upskilling programs, focusing on their design, implementation, and outcomes. Data sources include peer-reviewed journals and conference proceedings, selected based on criteria that ensure relevance and timeliness to the current IT context. Key findings reveal the critical need for anticipating technological trends to align workforce capabilities with future demands, highlighting the significance of personalized and experiential learning pathways. The study emphasizes the strategic role of upskilling in bridging the digital divide, advocating for inclusive and accessible learning opportunities to cultivate a diverse and globally competitive workforce. Recommendations for stakeholders center around adopting flexible learning models, fostering industry-academia partnerships, and emphasizing the development of both technical and soft skills. Finally, the study underscores the imperative for a proactive and collaborative approach to IT education and workforce development. By integrating advanced learning technologies and inclusive strategies, stakeholders can ensure the IT workforce remains agile and prepared to contribute innovatively in the face of technological advancements. This framework sets the foundation for future research and policy-making, aiming to enhance the resilience and diversity of the IT sector globally.
 Keywords:  Workforce Upskilling, Emerging Technologies, IT Education, Inclusive Learning Strategies.

A scoping review of racial, ethnic, socioeconomic, and geographic disparities in the outcomes of older adults with cancer.

Cancer health disparities are widespread. Nevertheless, the disparities in outcomes among diverse survivors of cancer ages 65 years and older ("older") have not been systematically evaluated. We conducted a scoping review of original research articles published between January 2016 and September 2023 and indexed in Medline (Ovid), Embase, Scopus, and CINAHL databases. We included studies evaluating racial, ethnic, socioeconomic disadvantaged, geographic, sexual and gender, and/or persons with disabilities disparities in treatment, survivorship, and mortality among older survivors of cancer. We excluded studies with no a priori aims related to a health disparity, review articles, conference proceedings, meeting abstracts, studies with unclear methodologies, and articles in which the disparity group was examined only as an analytic covariate. Two reviewers independently extracted data following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis reporting guidelines. After searching and removing duplicates, 2573 unique citations remained and after screening 59 articles met the inclusion criteria. Many investigated more than one health disparity, and most focused on racial and ethnic (n = 44) or socioeconomic (n = 25) disparities; only 10 studies described geographic disparities, and none evaluated disparities in persons with disabilities or due to sexual and gender identity. Research investigating disparities in outcomes among diverse older survivors of cancer is increasing gradually-68% of eligible articles were published between 2020 and 2023. Most studies focused on the treatment phase of care (n = 28) and mortality (n = 26), with 16 examined disparities in survivorship, symptoms, or quality of life. Most research was descriptive and lacked analyses of potential underlying mechanisms contributing to the reported disparities. Little research has evaluated the effect of strategies to reduce health disparities among older patients with cancer. This lack of evidence perpetuates cancer inequities and leaves the cancer care system ill equipped to address the unique needs of the rapidly growing and increasingly diverse older adult cancer population.

Home versus in-centre haemodialysis for people with kidney failure.

Home haemodialysis (HHD) may be associated with important clinical, social or economic benefits. However, few randomised controlled trials (RCTs) have evaluated HHD versus in-centre HD (ICHD). The relative benefits and harms of these two HD modalities are uncertain. This is an update of a review first published in 2014. This update includes non-randomised studies of interventions (NRSIs). To evaluate the benefits and harms of HHD versus ICHD in adults with kidney failure. We contacted the Information Specialist and searched the Cochrane Kidney and Transplant Register of Studies up to 9 October 2022 using search terms relevant to this review. Studies in the Register are identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Registry Platform (ICTRP) Search Portal, and ClinicalTrials.gov. We searched MEDLINE (OVID) and EMBASE (OVID) for NRSIs. RCTs and NRSIs evaluating HHD (including community houses and self-care) compared to ICHD in adults with kidney failure were eligible. The outcomes of interest were cardiovascular death, all-cause death, non-fatal myocardial infarction, non-fatal stroke, all-cause hospitalisation, vascular access interventions, central venous catheter insertion/exchange, vascular access infection, parathyroidectomy, wait-listing for a kidney transplant, receipt of a kidney transplant, quality of life (QoL), symptoms related to dialysis therapy, fatigue, recovery time, cost-effectiveness, blood pressure, and left ventricular mass. Two authors independently assessed if the studies were eligible and then extracted data. The risk of bias was assessed, and relevant outcomes were extracted. Summary estimates of effect were obtained using a random-effects model, and results were expressed as risk ratios (RR) and their 95% confidence intervals (CI) for dichotomous outcomes and mean difference (MD) or standardised mean difference (SMD) and 95% CI for continuous outcomes. Confidence in the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Meta-analysis was performed on outcomes where there was sufficient data. From the 1305 records identified, a single cross-over RCT and 39 NRSIs proved eligible for inclusion. These studies were of varying design (prospective cohort, retrospective cohort, cross-sectional) and involved a widely variable number of participants (small single-centre studies to international registry analyses). Studies also varied in the treatment prescription and delivery (e.g. treatment duration, frequency, dialysis machine parameters) and participant characteristics (e.g. time on dialysis). Studies often did not describe these parameters in detail. Although the risk of bias, as assessed by the Newcastle-Ottawa Scale, was generally low for most studies, within the constraints of observational study design, studies were at risk of selection bias and residual confounding. Many study outcomes were reported in ways that did not allow direct comparison or meta-analysis. It is uncertain whether HHD, compared to ICHD, may be associated with a decrease in cardiovascular death (RR 0.92, 95% CI 0.80 to 1.07; 2 NRSIs, 30,900 participants; very low certainty evidence) or all-cause death (RR 0.80, 95% CI 0.67 to 0.95; 9 NRSIs, 58,984 patients; very low certainty evidence). It is also uncertain whether HHD may be associated with a decrease in hospitalisation rate (MD -0.50 admissions per patient-year, 95% CI -0.98 to -0.02; 2 NRSIs, 834 participants; very low certainty evidence), compared with ICHD. Compared with ICHD, it is uncertain whether HHD may be associated with receipt of kidney transplantation (RR 1.28, 95% CI 1.01 to 1.63; 6 NRSIs, 10,910 participants; very low certainty evidence) and a shorter recovery time post-dialysis (MD -2.0 hours, 95% CI -2.73 to -1.28; 2 NRSIs, 348 participants; very low certainty evidence). It remains uncertain if HHD may be associated with decreased systolic blood pressure (SBP) (MD -11.71 mm Hg, 95% CI -21.11 to -2.46; 4 NRSIs, 491 participants; very low certainty evidence) and decreased left ventricular mass index (LVMI) (MD -17.74 g/m2, 95% CI -29.60 to -5.89; 2 NRSIs, 130 participants; low certainty evidence). There was insufficient data to evaluate the relative association of HHD and ICHD with fatigue or vascular access outcomes. Patient-reported outcome measures were reported using 18 different measures across 11 studies (QoL: 6 measures; mental health: 3 measures; symptoms: 1 measure; impact and view of health: 6 measures; functional ability: 2 measures). Few studies reported the same measures, which limited the ability to perform meta-analysis or compare outcomes. It is uncertain whether HHD is more cost-effective than ICHD, both in the first (SMD -1.25, 95% CI -2.13 to -0.37; 4 NRSIs, 13,809 participants; very low certainty evidence) and second year of dialysis (SMD -1.47, 95% CI -2.72 to -0.21; 4 NRSIs, 13,809 participants; very low certainty evidence). Based on low to very low certainty evidence, HHD, compared with ICHD, has uncertain associations or may be associated with decreased cardiovascular and all-cause death, hospitalisation rate, slower post-dialysis recovery time, and decreased SBP and LVMI. HHD has uncertain cost-effectiveness compared with ICHD in the first and second years of treatment. The majority of studies included in this review were observational and subject to potential selection bias and confounding, especially as patients treated with HHD tended to be younger with fewer comorbidities. Variation from study to study in the choice of outcomes and the way in which they were reported limited the ability to perform meta-analyses. Future research should align outcome measures and metrics with other research in the field in order to allow comparison between studies, establish outcome effects with greater certainty, and avoid research waste.

Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis.

Physical exercise is effective in managing Parkinson's disease (PD), but the relative benefit of different exercise types remains unclear. To compare the effects of different types of physical exercise in adults with PD on the severity of motor signs, quality of life (QoL), and the occurrence of adverse events, and to generate a clinically meaningful treatment ranking using network meta-analyses (NMAs). An experienced information specialist performed a systematic search for relevant articles in CENTRAL, MEDLINE, Embase, and five other databases to 17 May 2021. We also searched trial registries, conference proceedings, and reference lists of identified studies up to this date. We included randomized controlled trials (RCTs) comparing one type of physical exercise for adults with PD to another type of exercise, a control group, or both. Two review authors independently extracted data. A third author was involved in case of disagreements. We categorized the interventions and analyzed their effects on the severity of motor signs, QoL, freezing of gait, and functional mobility and balance up to six weeks after the intervention using NMAs. Two review authors independently assessed the risk of bias using the risk of bias 2 (RoB 2) tool and rated the confidence in the evidence using the CINeMA approach for results on the severity of motor signs and QoL. We consulted a third review author to resolve any disagreements. Due to heterogeneous reporting of adverse events, we summarized safety data narratively and rated our confidence in the evidence using the GRADE approach. We included 154 RCTs with a total of 7837 participants with mostly mild to moderate disease and no major cognitive impairment. The number of participants per study was small (mean 51, range from 10 to 474). The NMAs on the severity of motor signs and QoL included data from 60 (2721 participants), and 48 (3029 participants) trials, respectively. Eighty-five studies (5192 participants) provided safety data. Here, we present the main results. We observed evidence of beneficial effects for most types of physical exercise included in our review compared to a passive control group. The effects on the severity of motor signs and QoL are expressed as scores on the motor scale of the Unified Parkinson's Disease Rating Scale (UPDRS-M) and the Parkinson's Disease Questionnaire 39 (PDQ-39), respectively. For both scales, higher scores denote higher symptom burden. Therefore, negative estimates reflect improvement (minimum clinically important difference: -2.5 for UPDRS-M and -4.72 for PDQ-39). Severity of motor signs The evidence from the NMA (60 studies; 2721 participants) suggests that dance and gait/balance/functional training probably have a moderate beneficial effect on the severity of motor signs (dance: mean difference (MD) -10.18, 95% confidence interval (CI) -14.87 to -5.36; gait/balance/functional training: MD -7.50, 95% CI -11.39 to -3.48; moderate confidence), and multi-domain training probably has a small beneficial effect on the severity of motor signs (MD -5.90, 95% CI -9.11 to -2.68; moderate confidence). The evidence also suggests that endurance, aqua-based, strength/resistance, and mind-body training might have a small beneficial effect on the severity of motor signs (endurance training: MD -5.76, 95% CI -9.78 to -1.74; aqua-based training: MD -5.09, 95% CI -10.45 to 0.40; strength/resistance training: MD -4.96, 95% CI -9.51 to -0.40; mind-body training: MD -3.62, 95% CI -7.24 to 0.00; low confidence). The evidence is very uncertain about the effects of "Lee Silverman Voice training BIG" (LSVT BIG) and flexibility training on the severity of motor signs (LSVT BIG: MD -6.70, 95% CI -16.48 to 3.08; flexibility training: MD 4.20, 95% CI -1.61 to 9.92; very low confidence). Quality of life The evidence from the NMA (48 studies; 3029 participants) suggests that aqua-based training probably has a large beneficial effect on QoL (MD -15.15, 95% CI -23.43 to -6.87; moderate confidence). The evidence also suggests that mind-body, gait/balance/functional, and multi-domain training and dance might have a small beneficial effect on QoL (mind-body training: MD -7.22, 95% CI -13.57 to -0.70; gait/balance/functional training: MD -6.17, 95% CI -10.75 to -1.59; multi-domain training: MD -5.29, 95% CI -9.51 to -1.06; dance: MD -3.88, 95% CI -10.92 to 3.00; low confidence). The evidence is very uncertain about the effects of gaming, strength/resistance, endurance, and flexibility training on QoL (gaming: MD -8.99, 95% CI -23.43 to 5.46; strength/resistance training: MD -6.70, 95% CI -12.86 to -0.35; endurance training: MD -6.52, 95% CI -13.74 to 0.88; flexibility training: MD 1.94, 95% CI -10.40 to 14.27; very low confidence). Adverse events Only 85 studies (5192 participants) provided some kind of safety data, mostly only for the intervention groups. No adverse events (AEs) occurred in 40 studies and no serious AEs occurred in four studies. AEs occurred in 28 studies. The most frequently reported events were falls (18 studies) and pain (10 studies). The evidence is very uncertain about the effect of physical exercise on the risk of adverse events (very low confidence). Across outcomes, we observed little evidence of differences between exercise types. We found evidence of beneficial effects on the severity of motor signs and QoL for most types of physical exercise for people with PD included in this review, but little evidence of differences between these interventions. Thus, our review highlights the importance of physical exercise regarding our primary outcomes severity of motor signs and QoL, while the exact exercise type might be secondary. Notably, this conclusion is consistent with the possibility that specific motor symptoms may be treated most effectively by PD-specific programs. Although the evidence is very uncertain about the effect of exercise on the risk of adverse events, the interventions included in our review were described as relatively safe. Larger, well-conducted studies are needed to increase confidence in the evidence. Additional studies recruiting people with advanced disease severity and cognitive impairment might help extend the generalizability of our findings to a broader range of people with PD.

Epilepsy surgery in adults older than 50 years: A systematic review and meta-analysis.

Despite the general safety and efficacy of epilepsy surgery, there is evidence that epilepsy surgery remains underutilized. Although there are an increasing number of studies reporting epilepsy surgery in older adults, there is no consensus on whether epilepsy surgery is efficacious or safe for this population. Our objective was to systematically assess the efficacy as well as safety of resective surgery in people aged 50 years or older with drug-resistant epilepsy. We considered studies that examine the efficacy and safety of epilepsy surgery in adults aged 50 years and older. Study eligibility was limited to studies carried out after 1990, with a minimum of 10 participants and 6 months of follow-up. We searched the following databases for published studies: Ovid MEDLINE, Ovid Embase, Cumulative Index to Nursing and Allied Health Literature, PsychInfo, and Web of Science Conference Proceedings Citation Index - Science. The risk of bias of each included study was independently assessed by two reviewers using the MINORS (Methodological Index for Non-Randomized Studies) instrument. Eleven case series and 14 cohort studies met the criteria for inclusion, for a total of 1111 older adults who underwent epilepsy surgery along with 4111 adults younger than 50 years as control groups. The pooled cumulative incidence of older adults achieving seizure freedom after resective surgery was 70.1% (95% confidence interval [CI] = 65.3-74.7). There was no evident difference in the incidence of seizure freedom among older adults as compared to younger adults (risk ratio [RR] = 1.05, 95% CI = .97-1.14) in cohort studies. The pooled cumulative incidence of perioperative complications in older adults was 26.2% (95% CI = 21.3-31.7). Among them, 7.5% (95% CI = 5.8-9.5) experienced major complications. Older adults were significantly more at risk of experiencing any complication than younger adults (RR = 2.8, 95% CI = 1.5-5.4). Despite important considerations, epilepsy surgery may be considered appropriate among carefully selected individuals older than 50 years.

Gamification and Oral Health in Children and Adolescents: Scoping Review.

Oral health is a determinant of overall well-being and quality of life. Individual behaviors, such as oral hygiene and dietary habits, play a central role in oral health. Motivation is a crucial factor in promoting behavior change, and gamification offers a means to boost health-related knowledge and encourage positive health behaviors. This study aims to evaluate the impact of gamification and its mechanisms on oral health care of children and adolescents. A systematic search covered multiple databases: PubMed/MEDLINE, PsycINFO, the Cochrane Library, ScienceDirect, and LILACS. Gray literature, conference proceedings, and WHOQOL internet resources were considered. Studies from January 2013 to December 2022 were included, except for PubMed/MEDLINE, which was searched until January 2023. A total of 15 studies were selected following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The eligibility criteria were peer-reviewed, full-text, and empirical research related to gamification in oral health care, reports of impact, and oral health care outcomes. The exclusion criteria encompassed duplicate articles; unavailable full texts; nonoriginal articles; and non-digital game-related, non-oral health-related, and protocol studies. Selected studies were scrutinized for gamification mechanisms and outcomes. Two main questions were raised: "Does gamification in oral health care impact oral health?" and "Does oral health care gamification enhance health promotion and literacy?" The PICO (Patient, Intervention, Comparison, Outcome) framework guided the scoping review. Initially, 617 records were obtained from 5 databases and gray literature sources. After applying exclusion criteria, 15 records were selected. Sample size in the selected studies ranged from 34 to 190 children and adolescents. A substantial portion (11/15, 73%) of the studies discussed oral self-care apps supported by evidence-based oral health. The most clearly defined data in the apps were "brushing time" (11/11, 100%) and "daily amount brushing" (10/11, 91%). Most studies (11/15, 73%) mentioned oral health care behavior change techniques and included "prompt intention formation" (11/26, 42%), "providing instructions" (11/26, 42%), "providing information on the behavior-health link" (10/26, 38%), "providing information on consequences" (9/26, 35%), "modeling or demonstrating behavior" (9/26, 35%), "providing feedback on performance" (8/26, 31%), and "providing contingent rewards" (8/26, 31%). Furthermore, 80% (12/15) of the studies identified game design elements incorporating gamification features in oral hygiene applications. The most prevalent gamification features were "ideological incentives" (10/12, 83%) and "goals" (9/16, 56%), which were found in user-specific and challenge categories, respectively. Gamification in oral health care shows potential as an innovative approach to promote positive health behaviors. Most studies reported evidence-based oral health and incorporated oral health care behavior change techniques.

Where are you hiding the pangolins? screening tools to detect illicit contraband at international borders and their adaptability for illegal wildlife trafficking.

The illegal movement of wildlife poses a public health, conservation and biosecurity threat, however there are currently minimal screening tools available at international ports of entry to intercept wildlife trafficking efforts. This review first aimed to explore the screening tools available or under development for the detection of concealed wildlife contraband at international ports, including postal services, airlines, road border crossings and maritime routes. Where evidence was deficient, publications detailing the use of methods to uncover other illicit substances, such as narcotics, weapons, human trafficking, explosives, radioactive materials, or special nuclear material, were compiled and assessed for their applicability to the detection of wildlife. The first search identified only four citations related to the detection of wildlife, however the secondary search revealed 145 publications, including 59 journal articles and 86 conference proceedings, describing screening tools for non-wildlife illicit contraband detection. The screening tools uncovered were analysed for potential fitness for purpose for wildlife contraband detection, to evaluate the feasibility of their implementation and their ease of use. The deficiencies evident in terms of resource availability and research efforts targeting wildlife trafficking highlights a potentially substantial national and international security threat which must be addressed.

Accuracy of prenatal and postnatal biomarkers for estimating gestational age: a systematic review and meta-analysis

Knowledge of gestational age (GA) is key in clinical management of individual obstetric patients, and critical to be able to calculate rates of preterm birth and small for GA at a population level. Currently, the gold standard for pregnancy dating is measurement of the fetal crown rump length at 11-14 weeks of gestation. However, this is not possible for women first presenting in later pregnancy, or in settings where routine ultrasound is not available. A reliable, cheap and easy to measure GA-dependent biomarker would provide an important breakthrough in estimating the age of pregnancy. Therefore, the aim of this study was to determine the accuracy of prenatal and postnatal biomarkers for estimating gestational age (GA). Systematic review prospectively registered with PROSPERO (CRD42020167727) and reported in accordance with the PRISMA-DTA. Medline, Embase, CINAHL, LILACS, and other databases were searched from inception until September 2023 for cohort or cross-sectional studies that reported on the accuracy of prenatal and postnatal biomarkers for estimating GA. In addition, we searched Google Scholar and screened proceedings of relevant conferences and reference lists of identified studies and relevant reviews. There were no language or date restrictions. Pooled coefficients of correlation and root mean square error (RMSE, average deviation in weeks between the GA estimated by the biomarker and that estimated by the gold standard method) were calculated. The risk of bias in each included study was also assessed. Thirty-nine studies fulfilled the inclusion criteria: 20 studies (2,050 women) assessed prenatal biomarkers (placental hormones, metabolomic profiles, proteomics, cell-free RNA transcripts, and exon-level gene expression), and 19 (1,738,652 newborns) assessed postnatal biomarkers (metabolomic profiles, DNA methylation profiles, and fetal haematological components). Among the prenatal biomarkers assessed, human chorionic gonadotrophin measured in maternal serum between 4 and 9 weeks of gestation showed the highest correlation with the reference standard GA, with a pooled coefficient of correlation of 0.88. Among the postnatal biomarkers assessed, metabolomic profiling from newborn blood spots provided the most accurate estimate of GA, with a pooled RMSE of 1.03 weeks across all GAs. It performed best for term infants with a slightly reduced accuracy for preterm or small for GA infants. The pooled RMSEs for metabolomic profiling and DNA methylation profile from cord blood samples were 1.57 and 1.60 weeks, respectively. We identified no antenatal biomarkers that accurately predict GA over a wide window of pregnancy. Postnatally, metabolomic profiling from newborn blood spot provides an accurate estimate of GA, however, as this is known only after birth it is not useful to guide antenatal care. Further prenatal studies are needed to identify biomarkers that can be used in isolation, as part of a biomarker panel, or in combination with other clinical methods to narrow prediction intervals of GA estimation. The research was funded by the Bill and Melinda Gates Foundation (INV-000368). ATP is supported by the Oxford Partnership Comprehensive Biomedical Research Centre with funding from the NIHR Biomedical Research Centre funding scheme. The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR, the Department of Health, or the Department of Biotechnology. The funders of this study had no role in study design, data collection, analysis or interpretation of the data, in writing the paper or the decision to submit for publication.

Neoadjuvant Chemo-Immunotherapy for Early-Stage Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.

Randomized clinical trials (RCTs) with neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy (ICI-chemotherapy) for patients with early-stage non-small cell lung cancer (NSCLC) have reported consistent associations with event-free survival (EFS) and pathologic complete response (pCR) pending longer follow-up for overall survival data. To assess the pooled benefit of ICI-chemotherapy in 2-year EFS and pCR among patients with NSCLC and examine the impact of clinical, pathologic, and treatment-related factors. Full-text articles and abstracts in English were searched in EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews through November 1, 2023, and in oncology conference proceedings from January 1, 2008, to November 1, 2023. Phase 2 or 3 RCTs with neoadjuvant ICI-chemotherapy with or without adjuvant ICIs vs neoadjuvant chemotherapy alone with or without placebo or observation in patients with previously untreated NSCLC staged IB to IIIB were included. Data extraction of prespecified data elements was performed by 2 reviewers using a structured data abstraction electronic form. A random-effects model was used for meta-analysis. The meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Two-year EFS and pCR were the outcomes of interest in patients who received neoadjuvant ICI-chemotherapy (experimental arm) or neoadjuvant chemotherapy alone (control arm). Aggregated pooled hazard ratios (HRs) for time-to-event outcomes (2-year EFS) and risk ratios (RRs) for dichotomous outcomes (pCR) with their respective 95% CIs were calculated. Eight trials with 3387 patients were included, with some concerns of risk of bias as assessed by the Cochrane Collaboration method, mainly related to outcomes measurements. Neoadjuvant ICI-chemotherapy was associated with improved 2-year EFS (HR, 0.57; 95% CI, 0.50-0.66; P < .001) and increased pCR rate (RR, 5.58; 95% CI, 4.27-7.29; P < .001) in the experimental vs control treatment arms. This association was not significantly modified by the main patient characteristics; tumor- or treatment-related factors, including tumor programmed cell death ligand 1 (PD-L1) status; type of platinum-compound chemotherapy; number of cycles of neoadjuvant ICI-chemotherapy; or addition of adjuvant ICIs. Patients whose tumor cells were negative for PD-L1 were at higher risk of relapse (HR, 0.75; 95% CI, 0.62-0.91) than were those with low (HR, 0.61; 95% CI, 0.37-0.71) or high PD-L1 (HR, 0.40; 95% CI, 0.27-0.58) (P = .005). In this systematic review and meta-analysis of neoadjuvant ICI-chemotherapy RCTs in patients with early-stage NSCLC, 3 cycles of neoadjuvant platinum-based ICI-chemotherapy were associated with a meaningful improvement in 2-year EFS and pCR.

Analysis of Object Detection Models

Abstract: Object detection plays a crucial role in today’s world, and it gives direction in the field of computer vision. Object detection is a fundamental task used to detect the object in the images. Object detection plays a significant role in various applications such as surveillance, medical images, and autonomous vehicles. The primary goal of object detection is to accurately detect the boundaries of objects of interest and classify those objects into predefined categories. This paper analyzes three common object detection models: Single Shot Multibox Detector (SSD), You Only Look Once (YOLOv7), and You Only Look Once (YOLOv8). In this research work, both empirical and theoretical approaches were followed. The empirical study was carried out on a set of experiments using some software tools. For the theoretical approach, a review of both secondary data and data based on results obtained by applying the tools is studied. Secondary data was acquired from the books, e-journals, reports, review papers, published theses, websites, articles, conference proceedings, survey papers, and blogs that are related to this domain. The results that were obtained from this implementation were analyzed for the findings of the research. This paper compares three object detection model’s results, which are tested on the same dataset, the same environment, and the same system. This paper found that You Only Look Once (YOLOv8) obtained the best results, followed by You Only Look Once (YOLOv7) and Single Shot Multibox Detector (SSD) at last.

Publication Output and Trends of LIS Faculty Teaching Health-Related Courses: Connecting Research, Teaching, and Practice

The publication output of Library and Information Science (LIS) faculty teaching health courses has not been analyzed. The purpose of this bibliometric analysis was to examine publication patterns of full-time LIS faculty that teach health-related courses for library science programs in the United States and Canada. Full-time LIS faculty teaching health-related courses in American Library Association (ALA)–accredited programs were identified by searching course listings, faculty profiles, and syllabi from ALA-accredited school websites and contacting deans and directors of schools. The 29 LIS faculty that were identified and met the inclusion criteria were contacted via email in September 2021 and invited to voluntarily share their curricula vitae (CVs) for analysis. A total of 16 respondents provided their CVs, representing a 55% response rate. This was supplemented by locating five more CVs publicly available online. The final sample of LIS faculty was 21, and the bibliometrics analysis was based on a total of 716 publications published from 2011 to 2021 and reported on the CVs from this group of scholars. This analysis resulted in the identification of several patterns. Journal articles were the most common publication type, followed by conference proceedings. Joint authorship patterns were more common than solo authors, highlighting the collaborative nature of research. While faculty published in a range of LIS and interdisciplinary journals, highly cited papers appeared in health specialty journals. This study represents the first step in examining the research output for this under-explored community of LIS scholars. These findings may be of interest to promotion and tenure committees, newer tenure-track faculty, and doctoral students exploring academic careers in this specialized area.

Unlocking Secrets: Bioinformatics' Impact on Forensic Bio-Examinations

Bioinformatics (BI) is a diverse and interdisciplinary domain that studies biological data through computational techniques. Its rapid technological progress has led to a significant increase in biological data production, sparking a notable expansion in BI research and application. In recent years, the convergence between BI and forensic science has become increasingly evident, with the growing use of BI tools and techniques in forensic investigations. BI is not only extensively used in biomedical research to analyse biological data and forecast gene regulation but also in the development of drugs targeting disorders linked to epigenetic alterations. It merges principles from various fields like biology, computer science, and statistics to process extensive omics data, create databases, predict structures, and model metabolic processes. The impact of BI on biomedical research is substantial, aiding in data processing, prediction, and visualisation. Moreover, BI is increasingly important in analysing data generated through Sanger-based electrophoresis methods and massively parallel sequencing in forensic DNA analysis, demonstrating its practical application in the field. Therefore, BI plays a critical role in forensic identification, searching databases side by side, forensic DNA phenotyping and biographic ancestry, forensic genetic genealogy, and forensic epigenomics. An overview of different bioinformatic methodologies employed in forensic applications, exploring approaches for managing data and investigating trend analysis strategies within forensic contexts, is discussed. Additionally, it investigates data management strategies. The primary objective was to explore how BI facilitates forensic BI's use, integration, and impact. Utilising a systematic literature review and content analysis, the study examined peer-reviewed articles, conference proceedings, and reports from critical databases like Google Scholar and Scopus, focusing on publications from 2010 to 2024. Key findings highlight the significant advancements in genomic sequencing technologies and their application in personalised therapeutics. Forensic scientists can improve forensic exams' accuracy, reliability, and efficiency by using BI tools, metrics, and efficient data management procedures.

Preface: 3rd International Conference on Biotechnology, Life Science and Medical Engineering (BLSME 2024)

This conference proceedings volume contains the written versions of the contributions presented during the 2024 3rd International Conference on Biotechnology, Life Science and Medical Engineering (BLSME 2024), it had been held in Jeju, South Korea during January 13-14, 2024. This conference is the premier forum for the presentation of new advances and research results in the fields of biotechnology, bioengineering, biochemistry, preclinical medicine, clinical medicine, pharmacology, life science, medical engineering, and medicine technology.&#x0D; The conference provided a forum for discussion and sharing between lecturers, researchers, academics, practitioners, communities, and specialists, from universities, research institutes, corporations, industries, the government, and the public. The conference has been a great opportunity for participants coming from many countries to present and discuss topics in their respective research areas.&#x0D; BLSME 2024 conference included 4 plenary sessions and invited speakers, and oral and poster presentations to allow as many as possible attendances to present their scientific results on the different fields. The manuscripts which have presented were published under the peer-reviewed process.&#x0D; We would love to express our gratitude for all the participants, keynote speakers, and guests of honor, for their effective contribution in our conference. Our ongoing thankfulness is presented for our guest editors and speakers. Finally, we would love to express our gratefulness for all our sponsors, partners, and colleagues, we hope to collaborate with them in future activities.&#x0D; Chairman of Conference Committee&#x0D; Jeju, South Korea

31st Annual Scientific Meeting of Indian National Association for Study of the Liver (INASL 2023)

CONFERENCE PROCEEDINGS

Abstract 3813: Relationship between race/ethnicity and oncologic outcomes in patients with biochemical recurrence after primary treatment for prostate cancer

Abstract Background: Prostate cancer (PC) is the most common form of cancer in men and accounts for ~35% and 24% of all new cancer diagnoses in Black and Hispanic men, respectively. Incidence rates of PC are higher and cancer is diagnosed at a younger age in Black compared to White men. The most frequently utilized primary treatment options are radical prostatectomy (with or without adjuvant radiotherapy) or radiotherapy. Despite the success of primary treatments for localized PC, many patients (pts) will eventually develop biochemical recurrence (BCR), defined as rising prostate-specific antigen (PSA) levels. Pts with BCR are at a higher risk of developing distant metastases and ultimately dying from PC. This targeted literature review aimed to assess the real-world (RW) relationship between race/ethnicity and BCR, and further identify any differences in oncologic outcomes (risk of metastases, PC-specific mortality, and overall survival). Methods: A targeted literature search was performed using Embase, PubMed, and the past 2 years of American Society of Clinical Oncology conference proceedings. Selected studies were limited to English-language articles focusing on BCR and race or ethnicity among US populations, published between 1/2010 and 7/2023. Results: Ten studies were selected after title and abstract review. Most studies had a White pt majority (83%-92%). Six studies reported no differences in BCR or oncologic outcomes when pts were stratified by race/ethnicity. Four studies reported a higher BCR risk for Black pts with low-risk PC after radical prostatectomy, but not for pts with high-risk PC. PSA and PSA doubling time (PSADT) were found to be strong predictors of oncologic outcomes. Conclusions: The FDA draft guidance on diversity plans recommends that clinical trials enroll an adequate number of participants from underrepresented racial and ethnic populations. This requires an understanding of the diversity of the population that will eventually use the treatment and of which race/ethnicity differences in outcomes should be expected and investigated. Based on this targeted review among pts with localized PC, most RW studies had a White pt majority, and the race distribution in these studies aligned with published census and epidemiology data. In addition, findings suggest that race/ethnicity differences were not pronounced among high-risk PC pts in the US when given equal access to care or treatment, and that oncologic outcomes and BCR risk were similar across Black, White, and Hispanic pt populations. Conversely, PSA and PSADT may be stronger prognostic markers for BCR and oncologic outcomes. Future clinical trials are needed to support these RW findings and should aim to actively enroll racial/ethnic minorities to identify potential differences in efficacy and safety, and to help advance the evidence base for pt PC management. Citation Format: Nasreen Khan, Vanessa Quintero, Clara Beck, Miryana Dimova-Dobreva, Binita Patel. Relationship between race/ethnicity and oncologic outcomes in patients with biochemical recurrence after primary treatment for prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3813.

Mapping the Literature and Future Research Agenda of Employee Engagement: A Bibliometric Analysis of the past 20 years

Purpose: The aim of this study is to highlight the intricacies involved in the conceptualization and theorization of Employee Engagement in the past twenty years. By analyzing the antecedents and, this study aims to identify the gaps in the present literature so that future research directions can be deliberated.&#x0D; Design/methodology/approach: This research applies a bibliometric analysis approach in order to synthesize upcoming themes in the area of employee engagement.&#x0D; Findings: Employee Engagement as a concept has been widely conceptualized and mainly differentiated into two dimensions – psychological or attitudinal and behavioural.  Less research has taken place on the behavioural front of the topic wherein the extra-role performance by engaged employees’ discretionary behaviour should be studied. Also, factors like the nature of work and leadership, and emotional intelligence need attention.&#x0D; Limitations: The present study has only undertaken articles and has not focused on book chapters, conference proceedings and focused on English language research papers. Also, the study excluded research studies where engagement was examined as a moderator or mediator as the emphasis was on understanding the antecedents of engagement.&#x0D; Implications: Since engagement levels have dropped in the past decade, it becomes imperative for practitioners to overhaul it’s understanding and make every employee’s experience a unique one by engaging them.

Research of Innovation and Digital Transformation in Justice: A Systematic Review

Objective: To develop a mapping of studies on innovation and digital transformation in the justice sector, publishes from 2001 to 2022. Five research questions were defined: 1) How to define innovation and digital transformation introduced in the justice sector? 2) What types of innovations and digital transformations are implemented in the justice sector? 3) What are the objectives of introducing innovation and digital transformation in the justice sector? 4) What are the antecedents that influence the process of innovation and digital transformation in the justice sector? 5) What are the results of the innovation and digital transformation process in the justice sector?Methods: The systematic review of sources (scientific articles, conference proceedings, monographs and institutional documents) presented in this paper was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol. Selected by “research field”, “topic”, “research design”, “year of publication” and the keywords “public administration”, “public sector”, “e-justice”, “digital transformation”, and “innovation”, the sources were analyzed and evaluated according to five main aspects: (1) definition of innovation; (2) types of innovation; (3) objectives of innovation; (4) antecedents of innovation; and (5) results of innovation.Results: The heuristic model for studying innovation in the public sector developed by Vries et al. (2015) was adapted and applied to the research field of justice. The adaptation of the heuristic model allowed forming the following areas of analysis: contextual antecedents in justice; institutional antecedents in justice; characteristics of innovation and digital transformation in justice; individual antecedents in justice; types of innovation and digital transformation in justice; results of the process of innovation and digital transformation in justice.Scientific novelty: a comprehensive review of the literature in the field of innovation and digital transformation in justice is presented by adapting the approach to conducting systematic studies of the literature in the social sciences. It helped to identify gaps and define directions for further research in the given field, including the activation of comparative legal research, expansion of the methodological base, reliance on the theories of public administration, etc.Practical significance: the obtained results allow forming a heuristic map of innovation and digital transformation in justice, create antecedents (contextual, institutional and individual) and the basis for future empirical research in the field of justice, analysis, evaluation and improvement of public policy in the field of innovation and digital transformation in this area.